Recessive dystrophic epidermolysis bullosa is a severe skin fragility disease caused by loss of functional type VII collagen at the dermal-epidermal junction.A frameshift mutation in exon 80 of COL7A1 gene, c.6527insC, is highly prevalent in the Spanish patient population.We have implemented gene-editing strategies for COL7A1 frame restoration by N
Ion irradiation, combined with nanoindentation, has long been recognized as an effective way to study effects of irradiation on the mechanical properties of metallic materials.In this research, hardening and creep of ion irradiated Chinese low activation martensitic (CLAM) steel are investigated by nanoindentation.Firstly, it is demonstrated that i
Housing architecture in the Kampong Chinatown Karangturi - Lasem located in the North Coast of Java was the architecture of the Chinese community that had the character of the Chinese architectural style, this phenomenon is reinforced by the data entry of Chinese culture that took place since the 13th century.This study revealed how to understand t
The changes in the civil construction context, and consequently the production management of constructions, require a different profile engineer, which demands more refined skills from those professionals, such as innovation, focus on customer, production planning and control, quality management systems knowledge, sustainability and a humanist visi
Phenological events are good indicators of the effects of climate change, since phenological phases are sensitive to changes in environmental conditions.Although several national phenological networks monitor the phenology of different plant species, direct observations can only be conducted on individual trees, which cannot be easily extended over